Development and optimization of ketoconazole oral strips by means of continuous hot-melt extrusion processing
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چکیده
منابع مشابه
Development and optimization of ketoconazole oral strips by means of continuous hot-melt extrusion processing.
OBJECTIVES The aim of this study was to develop mucoadhesive oral strips using hot-melt extrusion as a continuous manufacturing process. METHODS Powder blends of ketoconazole, a water-insoluble drug - either hydroxypropyl methylcellulose (HPMC) or soluplus (SOL), sorbitol (SRB) and magnesium aluminometasilicate (MAS) were extruded to manufacture thin strips with 0.5-mm thickness. The presence...
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Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...
متن کاملHot-Melt Extrusion Technique: A Review
Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...
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ژورنال
عنوان ژورنال: Journal of Pharmacy and Pharmacology
سال: 2016
ISSN: 2042-7158,0022-3573
DOI: 10.1111/jphp.12569